What Causes High IgM Levels?

What is normal range for IgM?

Normal Ranges Adult: IgG 6.0 – 16.0g/L.

IgA 0.8 – 3.0g/L.

IgM 0.4 – 2.5g/L..

What is considered a high level of IgG?

High IgG (>16g/L) Elevated IgG levels can be seen in chronic active infection or inflammation, or in association with plasma cell disorders.

What does a positive Anticardiolipin IgM mean?

High levels of the IgM isotype are associated with autoimmune hemolytic anemia, a condition in which an individual’s immune system attacks their red blood cells.

What does it mean if your IgM is high?

IgM. High levels of IgM can mean macroglobulinemia, early viral hepatitis, mononucleosis, rheumatoid arthritis, kidney damage (nephrotic syndrome), or a parasite infection is present.

Does high IgM mean cancer?

Definition of Hyper IgM Syndromes , so patients with X-linked hyper IgM syndrome (XHIM) have defective cellular immunity and are also susceptible to all kinds of infections, particularly opportunistic infections and to some types of cancer.

Is High IgM serious?

Patients with hyper IgM are at significant risk for opportunistic and repeated infections. In addition, the defect in the immune system results in a decreased ability to identify and fight cancer cells as well as an inability to produce a response to pathogens.

What does an IgM blood test show?

Immunoglobulin M (IgM): Found mainly in blood and lymph fluid, this is the first antibody the body makes when it fights a new infection. Immunoglobulin E (IgE): Normally found in small amounts in the blood. There may be higher amounts when the body overreacts to allergens or is fighting an infection from a parasite.

What are IgM levels?

Immunoglobulin M: Your body makes IgM antibodies when you are first infected with new bacteria or other germs. They are your body’s first line of defense against infections. When your body senses an invader, your IgM level will rise for a short time.

Does M protein mean cancer?

Finding M proteins in the blood or urine is usually a sign of disease. Their presence is associated most commonly with a type of cancer of the plasma cells called multiple myeloma.

Does high protein in blood mean cancer?

A high total protein level could indicate dehydration or a certain type of cancer, such as multiple myeloma, that causes protein to accumulate abnormally. If the result of a total protein test is abnormal, further tests will be needed to identify which proteins are too high or too low.

What is a high level of M protein?

High levels of β2-M may indicate that a large number of myeloma cells is present and that kidney damage has occurred. The level of this protein increases as myeloma becomes more advanced. Lower amounts of serum albumin may indicate a poorer prognosis. Higher blood levels of LDH indicate a poorer prognosis.

What is the function of IgM?

IgM is present on B cells and its main function apparently is the control of B-cell activation. B-cells create IgM antibodies as a first line of defense. Their large size gives them excellent binding avidity, and can pick up trace amounts of infection to mark for recognition by phagocytes.

What is IgM quantitative?

Quantitative serum immunoglobulin tests are used to detect abnormal levels of the three major classes (IgG, IgA and IgM). Testing is used to help diagnose various conditions and diseases that affect the levels of one or more of these immunoglobulin classes.

What is chlamydia IgM?

The RIDASCREEN® Chlamydia trachomatis IgG/IgM test is a enzyme immunoassay for the determination of IgG and/or IgM antibodies against Chlamydia (C.) trachomatis in human serum. The test should be used for confirmation purposes when there is a suspected case of infection with C.

What does high cardiolipin IgM mean?

Platelets, blood cells that help blood to clot, also get used up, leading to problems with bleeding. The levels of these antibodies are often high in people with abnormal blood clotting, autoimmune diseases like systemic lupus erythematosus (SLE), or repeated miscarriages.

Which comes first IgG or IgM?

IgM antibody appears first, followed by IgA on mucosal surfaces or IgG in the serum. The IgG antibody is the major antibody of the response and is very stable, with a half-life of 7 to 21 days.

Is there a test to check your immune system?

Your doctor will also perform a physical examination. Tests used to diagnose an immune disorder include: Blood tests. Blood tests can determine if you have normal levels of infection-fighting proteins (immunoglobulin) in your blood and measure the levels of blood cells and immune system cells.